A Review of Hydroxypropyl Methyl Cellulose (HPMC) 200000 Unit

A Review of Hydroxypropyl Methyl Cellulose (HPMC) 200000 Unit

Hydroxypropyl Methyl Cellulose is a semi-synthetic, viscoelastic polymer which belongs to the cellulose ether family.hpmc 200000 unit It is soluble in cold water and some organic solvents but not in hot water.hpmc 200000 unit It is also non-ionic and non-toxic to humans. It has a wide application and can be used as thickener, emulsifier, film-former, binder, dispersing agent, and protective colloids. It is widely used in construction, pharmaceutical,food, detergent, paints, as well as a variety of other industrial applications.

Its ability to act as an emulsion stabilizer and a film former, as well as its resistance to moisture are key advantages of HPMC.hpmc 200000 unit In addition, its high tensile strength and modulus of elasticity allow it to withstand compression during packaging operations. These properties make it an ideal material for tablet cores and shells. It can also be used in the formation of coatings for tablets and other solid dosage forms, such as gummies and hard candy.

HPMC has a low level of toxicological concern, and its levels in food products are considered acceptable by the FDA.hpmc 200000 unit Moreover, it is safe for human use and has no significant effect on the growth of plants. It is a common food-grade excipient and is widely used in the manufacture of beverages, foods, medicines, cosmetics, and other consumer goods. In addition, it has been approved as an effective substitute for fat in many foods and can improve the physical properties of low-fat tofu.

The gelling properties of HPMC can be modified by varying the amount of alcohol and by altering the substituents on the hydroxypropyl methylcellulose ring.hpmc 200000 unit The present study explores the effects of different substitution patterns on the gelling behaviour of HPMC using Fourier transform infrared spectroscopy, Raman spectroscopy, small-amplitude oscillatory shear measurements, and rheology. The results indicate that the presence of alcohol enhances the rheological properties of HPMC, while substituents on the hydroxypropyl moiety of HPMC affect the gelling characteristics and structure.

A series of pulsatile release formulations of carbamazepine-nicotinamide (CBZ-NIC) cocrystal in aqueous and aqueous-organic solvent systems were prepared by adding different concentrations of hydroxypropyl methylcellulose.hpmc 200000 unit The onset time, dissolution rate, and the kinetics of release of CBZ-NIC were studied by differential scanning calorimetry, X-ray powder diffraction, and Raman spectroscopy. The resulting HPMC formulations showed good stability with respect to pulsatile release and exhibited an optimum lag time and sharp burst release.

Several studies comparing gelatin and HPMC capsules have been conducted.hpmc 200000 unit Kuentz M, Rothenhausler B, and Rothlisberger D found that gelatin capsules have higher stiffness and harder shells than HPMC capsules. However, HPMC capsules are soft and more elastomeric, and they absorb less water than gelatin capsules at a given humidity. This can help reduce abandon rates during automatic capsule filling machines. Moreover, they have better resistance to degradation by formaldehyde and can be made to contain lactose with ease. The performance of HPMC capsules was further characterized by M Sherry Ku et al using time domain 1H NMR.

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