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HPMC E5 Tablets for 3D Printer Printing and Orodispersible Films
HPMC E5 Tablets for 3D Printer Printing and Orodispersible Films
Hydroxypropyl methylcellulose(HPMC) is a semi-synthetic, viscoelastic polymer derived from cellulose and used in food processing and pharmaceutical applications.hpmc e5 It is available in a variety of grades based on its water-soluble properties and molecular weight, which are important factors to consider for the development of pharmaceutical dosage forms.hpmc e5 HPMC has good solubility and disintegration rate in water and can be dissolved in organic solvents as well as in water-organic solvent mixed solutions.hpmc e5 It also has a gelation property when heated. It is safe for human use and non-toxic to the environment, making it an ideal material for tablet manufacture.
The solubility of hpmc e5 depends on the degree of substitution and pH of the solution.hpmc e5 hpmc e5 Higher DS HPMCs tend to have a greater solubility in water than lower DS HPMCs. In addition, the hydroxypropyl groups on HPMC can be hydrated by various groups, which can also affect its solubility. The hydrogen bonding (HB) probability between an oxygen atom and a methyl group in the HPMC molecule is also important. HBs between adjacent methyl groups can create bridges, which inhibits water molecules from passing through the HPMC molecule. The HB probability decreases with increasing water content.
In this study, the printing dispersions containing HPMC E5 and HPMC E15 were evaluated for their flowability and extrudability during 3D printer printing and fabrication of orodispersible films.hpmc e5 The rheological behavior of the printing dispersions was assessed using shear stress-shear rate flow curves and a power law model.hpmc e5 All the dispersions displayed shear-thinning pseudoplastic behavior with a power index of approximately 0.80. The shape fidelity factor of the printing dispersions was close to one, indicating that they can be printed accurately and precisely. The phenytoin-loaded HPMC E15 ODFs exhibited excellent physical appearance, good mechanical strength and rapid disintegration time.
Adding carbomer to HPMC matrix tablets increased their stability and drug release rates.hpmc e5 However, the amount of nimodipine released from these formulations was not proportional to the carbomer ratio.hpmc e5 The rate of drug release was also influenced by the viscosity of the matrix and carbomer combination. In addition, the occurrence of anomalous diffusion and case II transport in these formulations was analyzed.
In this study, a novel slurry method was developed for the preparation of HPMC-based solid oral doses.hpmc e5 The slurry was prepared through a unique process, which prevented the aggregation and flocculation of powder particles and resulted in an improved dissolution rate.hpmc e5 The in vitro release of poorly soluble drugs from the slurry was controlled, and the results were characterized using the power law model. The two power law parameters, n and K, were found to be correlated with the viscosity of the HPMC-based solid SMES. These results suggest that the slurry method can be a viable platform for the preparation of aqueous SMES for poorly soluble drugs with high therapeutic potential.
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