HPMC K100M and Its Effect on Viscosity

HPMC K100M and Its Effect on Viscosity

Hydroxypropyl methylcellulose (HPMC) is a semisynthetic, inert, viscoelastic polymer derived from natural cellulose.hpmc k100 It is used in pharmaceutical formulations as an excipient and controlled-release component, found in tablets and capsules.hpmc k100 HPMC is available in different molecular weights and viscosities, which allow it to be used for specific formulation requirements. For example, HPMC K4M is typically used for formulations that require low to medium viscosity and good solubility, while HPMC K100M is commonly used as a matrix former and sustained-release component in tablets.

The rheological properties of aqueous HPMC solutions are highly dependent on its concentration and temperature.hpmc k100 As such, a thorough understanding of these factors is essential for formulating high-performance products with optimal processing and formulation.hpmc k100 The objective of this article was to study the effects of these variables on the rheology of ternary HPMC-PEG melt suspensions using surface plots. The results showed that the viscosity of a PEG-HPMC mixture largely depends on its concentration and grade. Furthermore, the viscosity of the ternary formulations was also greatly affected by the composition of the carbomer, which influences the dissolution rate and mechanism of drug liberation from the HPMC-carbomer matrix tablet.

In a simulated gastrointestinal tract, the release of metronidazole from an HPMC-carbomer matrix tablet is controlled by the pH within the gelled medium and the rate-controlling polymer.hpmc k100 To establish the best formulation of a Metronidazole-HPMC matrix tablet, we used mixture experimental design.hpmc k100 The drug release profiles and mechanisms were optimized using the numerical optimization procedure. The optimum formulation demonstrated a case II transport behavior and the drug was released through a dissolution pore in the gastrointestinal tract.

This paper evaluates the effect of different grades and concentrations of HPMC on aqueous solution viscosity, which is important for the proper preparation of tablets.hpmc k100 The viscosity of a ternary HPMC-carbomer-drug formulation increases proportionally to the drug loading and inversely to the temperature of the HPMC.hpmc k100 This can be explained by the fact that a higher concentration of HPMC retards the flow of the polymer melt, thereby increasing its viscosity. However, the viscosity of a ternary formulation decreases with an increase in the concentration of the carbomer, which is due to its lower molecular weight and viscosity.

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