Low Viscosity HPMC

Low Viscosity HPMC

HPMC is a semi-synthetic, inert and viscoelastic polymer composed of methylcellulose with small amounts of hydroxypropyl and methoxyl substitutions.hpmc low viscosity The varying ratios of these substitutions affect the polymer’s hydrophilicity, gelling behaviour, rheology and film properties. It is a very popular material used in various applications such as tablet coating and nebulisation, where low viscosity is required. There are different grades of HPMC, with their initial letters indicating the varying substitutions: K, E and F (Table 1).

The molecular weight of HPMC can impact its stability in solution, with higher molecular weight grades degrading faster than lower molecular weight grades.hpmc low viscosity However, the manufacturer of low viscosity HPMC grades such as MOBS 3P4 and 6P4, Shin-Etsu, has confirmed that these low molecular weight grades have stability and aging properties equal to or better than high molecular weight methylcellulose.

In the rheometer, the ternary melt suspensions of each grade of HPMC displayed a wide range of viscosities over the temperature range studied.hpmc low viscosity Detailed comparison of the viscosities at each temperature and concentration was difficult due to the large number of formulations investigated. PCA was used to create a scores plot of the data, allowing easier identification of distinct groups of formulations with similar viscosities. The four groups identified in the scores plot were then analysed using a line graph and a table to compare the characteristics of each group.

Analysis of the groups showed that at high HPMC concentrations, particle-particle interactions predominated.hpmc low viscosity This is not surprising, given the large differences in the ratios of hydroxypropyl to methoxyl substitution between the HPMC grades. In addition, the viscosity profiles of different grades of HPMC intersected at certain temperatures, making it difficult to rank them according to their ability to suppress particle-particle interactions.

Consumption of the low viscosity hpmc (ULV-HPMC) profoundly improves glucose control and reduces visceral adiposity and liver lipid accumulation in Zucker Diabetic Fatty rats compared to those fed non-viscous cellulose (control).hpmc low viscosity The results suggest that ULV-HPMC has the potential to be incorporated into clinical treatment regimens for type 2 diabetes. Further research is necessary to explore the cellular mechanisms of this effect. In addition, the ability to nebulise ULV-HPMC at higher concentrations (5 wt%) than traditional materials would allow for more flexible treatment schedules. Moreover, the treatment could be easily combined with other therapies such as dietary modification or exercise to maximize efficacy. Despite its many advantages, the use of ULV-HPMC has not yet been widely adopted by nebulizer manufacturers due to the lack of available nebulizers that are compatible with this material. This is expected to change as more nebulizers are developed to accommodate this new material.

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